il Wayne has reportedly been taken to hospital after suffering a seizure and being found unconscious in his hotel room in Chicago.
Reports say the 34-year-old rapper, who has epilepsy, suffered a number of fits and had another one after arriving at A&E.
He had been due to perform in Las Vegas on Sunday night.
The rap star, whose real name is Dwayne Michael Carter Jr, was treated a year ago after suffering two minor seizures.
Four years ago Lil Wayne spent several days at a hospital in Los Angeles.
After those seizures the rapper told a radio station that he was epileptic and prone to having fits.
Lil Wayne says he suffers seizures because of stress, lack of rest and overworking himself.
Worried fans have been tweeting #prayforweezy after his latest seizures were reported.